Compound Detail
CHEMBL37373
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Basic Information
| ChEMBL ID | CHEMBL37373 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | PUGPTATVELXSCS-UHFFFAOYSA-N |
1
Targets
3
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
410.3
MW (Da)
4.65
ALogP
5
HBA
1
HBD
46.0
PSA (Ų)
0.52
QED
0
Ro5 Violations
5
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 3 meas. best 7.39
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Epidermal growth factor receptor CHEMBL203 | IC50 | 7.39 | 7.0233 | 41.0 | 3 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Epidermal growth factor receptor | IC50 | = | 41.0 | nM | 7.39 | Inhibition of the phosphorylation of a random polyglutamic acid/tyrosine copolym... | 9154973 |
| Epidermal growth factor receptor | IC50 | = | 145.0 | nM | 6.84 | Inhibition of autophosphorylation of epidermal growth factor receptor prepared f... | 9154973 |
| Epidermal growth factor receptor | IC50 | = | 144.54 | nM | 6.84 | Inhibition autophosphorylation of EGFR in human DiFi cells after 2 hrs by ELISA | 17689836 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 9154973 | 10.1021/jm960789h | Epidermal growth factor receptor | 2 |
| 17689836 | 10.1016/j.ejmech.2007.06.006 | Epidermal growth factor receptor | 1 |
Data from ChEMBL 36 via Core Engine