Compound Detail
CHEMBL39355
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Basic Information
| ChEMBL ID | CHEMBL39355 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | JZIOODYWXRIKDF-UHFFFAOYSA-N |
1
Targets
2
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
467.4
MW (Da)
4.21
ALogP
7
HBA
1
HBD
68.1
PSA (Ų)
0.46
QED
0
Ro5 Violations
6
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 8.06
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Epidermal growth factor receptor CHEMBL203 | IC50 | 8.06 | 7.585 | 8.8 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Epidermal growth factor receptor | IC50 | = | 8.8 | nM | 8.06 | Inhibition of the phosphorylation of a random polyglutamic acid/tyrosine copolym... | 9154973 |
| Epidermal growth factor receptor | IC50 | = | 77.0 | nM | 7.11 | Inhibition of autophosphorylation of epidermal growth factor receptor prepared f... | 9154973 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 9154973 | 10.1021/jm960789h | Epidermal growth factor receptor | 2 |
Data from ChEMBL 36 via Core Engine