Compound Detail
CHEMBL375655
GUANOSINE Enter ChEMBL ID:
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Basic Information
| ChEMBL ID | CHEMBL375655 |
| Name | GUANOSINE |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | NYHBQMYGNKIUIF-UUOKFMHZSA-N |
3
Targets
5
Activities
3
Assay Types
1
PK Parameters
20
Publications
0
Known Names
Molecular Properties
283.2
MW (Da)
-2.69
ALogP
9
HBA
5
HBD
159.5
PSA (Ų)
0.40
QED
0
Ro5 Violations
2
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 3 meas. best 7.0
EC50 1 meas. best 7.52
Ki 1 meas.
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Vero CHEMBL391 | EC50 | 7.52 | 7.52 | 30.0 | 1 |
| T-cell CHEMBL614309 | IC50 | 7.0 | 7.0 | 100.0 | 1 |
| NON-PROTEIN TARGET CHEMBL3879801 | IC50 | 5.16 | 5.16 | 7000.0 | 1 |
Pharmacokinetic Data
| Parameter | Value | Units | Species |
|---|---|---|---|
| T1/2 | 0.004028 | hr | Rattus norvegicus |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Vero | EC50 | = | 30.0 | nM | 7.52 | Antiviral activity against Vero cells, infected with HSV-1 | 1720175 |
| T-cell | IC50 | = | 100.0 | nM | 7.0 | Compound was tested for its cytotoxicity against T- cell line | 3783596 |
| NON-PROTEIN TARGET | IC50 | = | 7000.0 | nM | 5.16 | Compound was tested for its cytotoxicity against MGL-8 B -lymphoblasts | 3783596 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 17060520 | 10.1128/aac.00790-06 | Vero | 7 |
| 12781179 | 10.1016/s0960-894x(03)00331-7 | Adenosylhomocysteinase | 3 |
| 21928782 | 10.1021/np200591h | SH-SY5Y | 3 |
| 21682262 | 10.1021/np2001557 | SH-SY5Y | 3 |
| 1720175 | 10.1021/jm00115a022 | ADMET | 2 |
| - | 10.6019/CHEMBL4808148 | Histone deacetylase 6 | 2 |
| 26883470 | 10.1021/acs.jnatprod.5b00987 | Unchecked | 2 |
| 31484 | 10.1021/jm00207a008 | Purine nucleoside phosphorylase | 2 |
| 22705000 | 10.1016/j.ejmech.2012.04.045 | Liver | 2 |
| 20921305 | 10.1128/aac.01029-10 | Bacillus anthracis | 2 |
| 3861870 | 10.1021/jm00147a012 | Friend leukemia cell line | 2 |
| 1720175 | 10.1021/jm00115a022 | Vero | 2 |
| 17060520 | 10.1128/aac.00790-06 | Unchecked | 1 |
| 3861870 | 10.1021/jm00147a012 | HL-60 | 1 |
| 20921305 | 10.1128/aac.01029-10 | J774.A1 | 1 |
| 21840216 | 10.1016/j.bmcl.2011.07.054 | Unchecked | 1 |
| 6991691 | 10.1021/jm00178a002 | Hypoxanthine-guanine phosphoribosyltransferase | 1 |
| 6991691 | 10.1021/jm00178a002 | Plasmodium berghei | 1 |
| 3783596 | 10.1021/jm00161a041 | NON-PROTEIN TARGET | 1 |
| 3783596 | 10.1021/jm00161a041 | T-cell | 1 |
Data from ChEMBL 36 via Core Engine