Compound Detail
CHEMBL3759253
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Basic Information
| ChEMBL ID | CHEMBL3759253 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | SNYVZWBGTUFKJH-UHFFFAOYSA-N |
3
Targets
3
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
378.5
MW (Da)
5.91
ALogP
2
HBA
1
HBD
42.0
PSA (Ų)
0.47
QED
1
Ro5 Violations
5
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 3 meas. best 9.7
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Protein-serine O-palmitoleoyltransferase porcupine CHEMBL1255164 | IC50 | 9.7 | 9.7 | 0.2 | 1 |
| Protein Wnt-3a CHEMBL1255137 | IC50 | 9.62 | 9.62 | 0.2 | 1 |
| Molecular identity unknown CHEMBL612546 | IC50 | 8.54 | 8.54 | 2.9 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Protein-serine O-palmitoleoyltransferase porcupine | IC50 | = | 0.2 | nM | 9.7 | Inhibition of PORCN in mouse Leydig cells overexpressing Wnt3A co-cultured with ... | 27437076 |
| Protein Wnt-3a | IC50 | = | 0.24 | nM | 9.62 | Wnt-Luc Reporter Assay: Human embryonic kidney 293 cells (obtained from American... | - |
| Molecular identity unknown | IC50 | = | 2.9 | nM | 8.54 | Inhibition of Wnt signaling (unknown origin) expressed in mouse L Wnt3A cells co... | 26647303 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 26647303 | 10.1016/j.ejmech.2015.11.026 | Molecular identity unknown | 1 |
| 27437076 | 10.1021/acsmedchemlett.6b00038 | Protein-serine O-palmitoleoyltransferase porcupine | 1 |
Data from ChEMBL 36 via Core Engine