Compound Detail
CHEMBL3770214
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Basic Information
| ChEMBL ID | CHEMBL3770214 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | XEDBHRINPFDNQZ-UHFFFAOYSA-N |
2
Targets
4
Activities
1
Assay Types
0
PK Parameters
4
Publications
0
Known Names
Molecular Properties
343.4
MW (Da)
3.22
ALogP
5
HBA
0
HBD
64.8
PSA (Ų)
0.68
QED
0
Ro5 Violations
4
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 4 meas. best 6.24
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Bromodomain adjacent to zinc finger domain protein 2A CHEMBL3108642 | IC50 | 6.24 | 6.24 | 580.0 | 2 |
| Bromodomain adjacent to zinc finger domain protein 2B CHEMBL1741220 | IC50 | 6.09 | 6.09 | 820.0 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Bromodomain adjacent to zinc finger domain protein 2A | IC50 | = | 580.0 | nM | 6.24 | Inhibition of recombinant His6-TEV fused human BAZ2A expressed in Escherichia co... | 25799074 |
| Bromodomain adjacent to zinc finger domain protein 2A | IC50 | = | 580.0 | nM | 6.24 | Displacement of biotinylated peptide from recombinant His6-TEV fused human BAZ2A... | 25799074 |
| Bromodomain adjacent to zinc finger domain protein 2B | IC50 | = | 820.0 | nM | 6.09 | Inhibition of recombinant His6-TEV fused human BAZ2B expressed in Escherichia co... | 25799074 |
| Bromodomain adjacent to zinc finger domain protein 2B | IC50 | = | 820.0 | nM | 6.09 | Displacement of biotinylated peptide from recombinant His6-TEV fused human BAZ2B... | 25799074 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 25799074 | 10.1021/acs.jmedchem.5b00209 | Bromodomain adjacent to zinc finger domain protein 2A | 2 |
| 25799074 | 10.1021/acs.jmedchem.5b00209 | Bromodomain adjacent to zinc finger domain protein 2B | 2 |
| 25799074 | 10.1021/acs.jmedchem.5b00209 | Bromodomain-containing protein 4 | 2 |
| 25799074 | 10.1021/acs.jmedchem.5b00209 | Bromodomain-containing protein 9 | 2 |
Data from ChEMBL 36 via Core Engine