Compound Detail
CHEMBL377727
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Basic Information
| ChEMBL ID | CHEMBL377727 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | NDVGZMNSCFPVKF-UHFFFAOYSA-N |
3
Targets
3
Activities
1
Assay Types
0
PK Parameters
5
Publications
0
Known Names
Molecular Properties
321.1
MW (Da)
4.69
ALogP
2
HBA
0
HBD
17.8
PSA (Ų)
0.75
QED
0
Ro5 Violations
1
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 3 meas. best 7.72
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Unchecked CHEMBL612545 | IC50 | 7.72 | 7.72 | 19.0 | 1 |
| GABA receptor subunit CHEMBL3986 | IC50 | 7.08 | 7.08 | 83.0 | 1 |
| GABA-A receptor; anion channel CHEMBL2094133 | IC50 | 5.8 | 5.8 | 1600.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Unchecked | IC50 | = | 19.0 | nM | 7.72 | Selectivity for housefly GABA receptor over mouse GABA receptor | 16386419 |
| GABA receptor subunit | IC50 | = | 83.0 | nM | 7.08 | Displacement of [3H]EBOB from housefly neuronal membrane GABA receptor | 16386419 |
| GABA-A receptor; anion channel | IC50 | = | 1600.0 | nM | 5.8 | Binding affinity to mouse brain GABA receptor | 16386419 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 16386419 | 10.1016/j.bmcl.2005.12.012 | Ctenocephalides felis | 3 |
| 16386419 | 10.1016/j.bmcl.2005.12.012 | GABA-A receptor; anion channel | 1 |
| 16386419 | 10.1016/j.bmcl.2005.12.012 | Unchecked | 1 |
| 16386419 | 10.1016/j.bmcl.2005.12.012 | Musca domestica | 1 |
| 16386419 | 10.1016/j.bmcl.2005.12.012 | GABA receptor subunit | 1 |
Data from ChEMBL 36 via Core Engine