Compound Detail
CHEMBL378571
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
NC(=O)C[C@H](N)C(=O)N[C@H](Cc1ccccc1)C(=O)N1C[C@H](OCc2ccc3ccccc3c2)C[C@H]1CCCN=C(N)N
Basic Information
| ChEMBL ID | CHEMBL378571 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | MNJTTYMJKZNPFK-ZZXHUEHTSA-N |
3
Targets
6
Activities
2
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
587.7
MW (Da)
1.31
ALogP
6
HBA
5
HBD
192.2
PSA (Ų)
0.11
QED
1
Ro5 Violations
14
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 3 meas. best 6.4
Ki 3 meas. best 6.35
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Melanocyte-stimulating hormone receptor CHEMBL3795 | EC50 | 6.4 | 6.4 | 402.0 | 1 |
| Melanocyte-stimulating hormone receptor CHEMBL3795 | Ki | 6.35 | 6.35 | 443.0 | 1 |
| Melanocortin receptor 4 CHEMBL259 | Ki | 5.18 | 5.18 | 6666.0 | 1 |
| Melanocortin receptor 3 CHEMBL4644 | Ki | 4.81 | 4.81 | 15358.0 | 1 |
| Melanocortin receptor 4 CHEMBL259 | EC50 | 4.7 | 4.7 | 20000.0 | 1 |
| Melanocortin receptor 3 CHEMBL4644 | EC50 | 4.7 | 4.7 | 20000.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Melanocyte-stimulating hormone receptor | EC50 | = | 402.0 | nM | 6.4 | Agonist activity at human MC1R transfected in HEK293 cells | 16854081 |
| Melanocyte-stimulating hormone receptor | Ki | = | 443.0 | nM | 6.35 | Displacement of europium labeled NDP-alpha-MSH from human MC1R expressed in HEK2... | 16854081 |
| Melanocortin receptor 4 | Ki | = | 6666.0 | nM | 5.18 | Displacement of europium labeled NDP-alpha-MSH from human MC4R expressed in HEK2... | 16854081 |
| Melanocortin receptor 3 | Ki | = | 15358.0 | nM | 4.81 | Displacement of europium labeled NDP-alpha-MSH from human MC3R expressed in HEK2... | 16854081 |
| Melanocortin receptor 4 | EC50 | = | 20000.0 | nM | 4.7 | Agonist activity at human MC4R transfected in HEK293 cells | 16854081 |
| Melanocortin receptor 3 | EC50 | = | 20000.0 | nM | 4.7 | Agonist activity at human MC3R transfected in HEK293 cells | 16854081 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 16854081 | 10.1021/jm060384p | Melanocortin receptor 4 | 3 |
| 16854081 | 10.1021/jm060384p | Melanocortin receptor 3 | 3 |
| 16854081 | 10.1021/jm060384p | Melanocyte-stimulating hormone receptor | 3 |
Data from ChEMBL 36 via Core Engine