Compound Detail
CHEMBL388597
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Basic Information
| ChEMBL ID | CHEMBL388597 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | JYCMBBDSOIHJNA-CBPNBUAGSA-N |
1
Targets
2
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
291.3
MW (Da)
-1.62
ALogP
10
HBA
4
HBD
169.1
PSA (Ų)
0.51
QED
0
Ro5 Violations
2
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 6.33
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Human gammaherpesvirus 8 CHEMBL612780 | IC50 | 6.33 | 6.07 | 470.0 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Human gammaherpesvirus 8 | IC50 | = | 470.0 | nM | 6.33 | Cytotoxicity against Kaposi's sarcoma-associated herpesvirus infected BC3 cells ... | 17402726 |
| Human gammaherpesvirus 8 | IC50 | = | 1560.0 | nM | 5.81 | Cytotoxicity against Kaposi's sarcoma-associated herpesvirus infected BC2 cells ... | 17402726 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 17402726 | 10.1021/jm070032y | Human gammaherpesvirus 8 | 2 |
| 17402726 | 10.1021/jm070032y | ADMET | 1 |
Data from ChEMBL 36 via Core Engine