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Target Snapshot

CHEMBL612780 Target Snapshot

Human gammaherpesvirus 8 · ORGANISM · Human gammaherpesvirus 8

53Compounds
13Assays
2Approved Drugs
64.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

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Review focus
Open DB context pending

Confirm a stable target identifier before relying on this context across project surfaces.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Human gammaherpesvirus 8 as ChEMBL target CHEMBL612780. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Human gammaherpesvirus 8
ORGANISM · Human gammaherpesvirus 8
As of 2026-09-14
ChEMBL target ID
CHEMBL612780
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

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UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Human gammaherpesvirus 8 still has a stable protein naming contract across sources.

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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
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Overview

Basic Information

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UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelHuman gammaherpesvirus 8
UniProt AccessionN/A

Human gammaherpesvirus 8

Source · UniProt accession via ChEMBL component mapping
Review Cue

How to read this target

Review this target as Human gammaherpesvirus 8.

Review nameHuman gammaherpesvirus 8
OrganismHuman gammaherpesvirus 8
Clinical Profile

Clinical Phase Distribution

2
Approved
2
Phase II
Assay Mix

Activity Type Distribution

IC5061.0
EC503.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL5314375 7.19 EC50 64.0 Approved
CHEMBL337450 6.89 IC50 130.0 Clinical
CHEMBL388597 6.33 IC50 470.0 Preclinical
CHEMBL448168 6.1 IC50 790.0 Preclinical
CHEMBL438117 5.94 IC50 1140.0 Preclinical
CHEMBL388794 5.83 IC50 1480.0 Preclinical
CHEMBL227992 5.76 IC50 1730.0 Preclinical
CHEMBL265948 5.52 IC50 3000.0 Clinical
CHEMBL226395 4.89 IC50 13000.0 Preclinical
CHEMBL127498 4.85 EC50 14200.0 Preclinical
Distribution

pChEMBL Value Distribution

1
5.0
8
5.5
2
6.0
2
6.5
1
7.0
0
7.5
0
8.0
0
8.5
0
9.0
0
9.5
pChEMBL
Approved Drugs

Approved Drugs

CIDOFOVIR
CHEMBL5314375
Approved 1996
Assay Landscape

Assay Landscape

13
Total Assays
23
Tested Compounds
1
Assay Types
Functional — 13 assays, 23 compounds
BAO Format Assays Compounds Avg pChEMBL
organism-based format 13 23 5.3

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine