Compound Detail
CHEMBL448168
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Basic Information
| ChEMBL ID | CHEMBL448168 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | VDRUZJMHFSOKMC-MCOSLZNDSA-N |
1
Targets
2
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
306.3
MW (Da)
-1.19
ALogP
10
HBA
3
HBD
152.3
PSA (Ų)
0.63
QED
0
Ro5 Violations
3
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 6.1
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Human gammaherpesvirus 8 CHEMBL612780 | IC50 | 6.1 | 5.96 | 790.0 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Human gammaherpesvirus 8 | IC50 | = | 790.0 | nM | 6.1 | Cytotoxicity against Kaposi's sarcoma-associated herpesvirus infected BC3 cells ... | 17402726 |
| Human gammaherpesvirus 8 | IC50 | = | 1510.0 | nM | 5.82 | Cytotoxicity against Kaposi's sarcoma-associated herpesvirus infected BC2 cells ... | 17402726 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 17402726 | 10.1021/jm070032y | Human gammaherpesvirus 8 | 2 |
| 17402726 | 10.1021/jm070032y | ADMET | 1 |
Data from ChEMBL 36 via Core Engine