Assay Detail
Functional
CHEMBL917890
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Cytotoxicity against Kaposi's sarcoma-associated herpesvirus infected BC3 cells after 120 hrs by MTT assay
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human gammaherpesvirus 8 |
| Cell Type | BC-3 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
9-(2-C-Cyano-2-deoxy-beta-D-arabino-pentofuranosyl)guanine, a potential antitumor agent against B-lymphoma infected with Kaposi's sarcoma-associated herpesvirus.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 5.82 | 6.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL337450 | TAS-109 | 2.0 | 1 | 6.64 |
| CHEMBL388597 | — | — | 1 | 6.33 |
| CHEMBL448168 | — | — | 1 | 6.10 |
| CHEMBL438117 | — | — | 1 | 5.94 |
| CHEMBL388794 | — | — | 1 | 5.83 |
| CHEMBL227992 | — | — | 1 | 5.76 |
| CHEMBL182 | GANCICLOVIR | 4.0 | 1 | 4.16 |
| CHEMBL31634 | BRIVUDINE | 2.0 | 1 | - |
| CHEMBL184 | ACYCLOVIR | 4.0 | 1 | - |
| CHEMBL337389 | — | — | 1 | - |
| CHEMBL268120 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL337450 | TAS-109 | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL388597 | — | IC50 | = | 470.0 | nM | 6.33 |
| CHEMBL448168 | — | IC50 | = | 790.0 | nM | 6.10 |
| CHEMBL438117 | — | IC50 | = | 1140.0 | nM | 5.94 |
| CHEMBL388794 | — | IC50 | = | 1480.0 | nM | 5.83 |
| CHEMBL227992 | — | IC50 | = | 1730.0 | nM | 5.76 |
| CHEMBL182 | GANCICLOVIR | IC50 | = | 70000.0 | nM | 4.16 |
| CHEMBL31634 | BRIVUDINE | IC50 | > | 15000.0 | nM | - |
| CHEMBL184 | ACYCLOVIR | IC50 | > | 100000.0 | nM | - |
| CHEMBL337389 | — | IC50 | > | 15000.0 | nM | - |
| CHEMBL268120 | — | IC50 | > | 15000.0 | nM | - |