Compound Detail
CHEMBL3915626
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Cn1nc(C(C)(C)C)cc1C(=O)Nc1cccc(C(=O)c2ccc3c(/C=C/c4ccccn4)n[nH]c3c2)c1
Basic Information
| ChEMBL ID | CHEMBL3915626 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | DLOIETYWULEDMH-WYMLVPIESA-N |
2
Targets
2
Activities
2
Assay Types
6
PK Parameters
0
Publications
0
Known Names
Molecular Properties
504.6
MW (Da)
5.64
ALogP
6
HBA
2
HBD
105.6
PSA (Ų)
0.29
QED
2
Ro5 Violations
6
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 7.55
Ki 1 meas. best 9.7
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Vascular endothelial growth factor receptor 2 CHEMBL279 | Ki | 9.7 | 9.7 | 0.2 | 1 |
| NON-PROTEIN TARGET CHEMBL3879801 | IC50 | 7.55 | 7.55 | 28.0 | 1 |
Pharmacokinetic Data
| Parameter | Value | Units | Species |
|---|---|---|---|
| AUC | 9066.0 | ng.hr.mL-1 | Mus musculus |
| AUC | 9408.0 | ng.hr.mL-1 | Mus musculus |
| Cmax | 4449.16 | nM | Mus musculus |
| Cmax | 3916.05 | nM | Mus musculus |
| T1/2 | 1.9 | hr | Mus musculus |
| T1/2 | 3.2 | hr | Mus musculus |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Vascular endothelial growth factor receptor 2 | Ki | = | 0.2 | nM | 9.7 | Inhibition of unphosphorylated human 50 residues truncated cytoplasmic domain of... | - |
| NON-PROTEIN TARGET | IC50 | = | 28.0 | nM | 7.55 | Antiproliferative activity against VEGF-stimulated HUVEC cells assessed as reduc... | - |
Data from ChEMBL 36 via Core Engine