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Compound Detail

CHEMBL39286

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C[C@@H]1c2ccccc2N(C)[C@@H]1C1=NCCN1

Basic Information

ChEMBL ID CHEMBL39286
Phase Preclinical
Structure Type MOL
InChI Key HFLSCUSXYKBPTL-SKDRFNHKSA-N
1
Targets
2
Activities
2
Assay Types
0
PK Parameters
2
Publications
0
Known Names

Molecular Properties

215.3
MW (Da)
1.61
ALogP
3
HBA
1
HBD
27.6
PSA (Ų)
0.77
QED
0
Ro5 Violations
1
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C13H17N3
MW 215.30
Aromatic Rings 1
Heavy Atoms 16
NP-Likeness 0.33

Activity Summary

IC50 1 meas. best 8.48
Ki 1 meas. best 8.16

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Adrenergic receptor alpha-2
CHEMBL2093864
IC50 8.48 8.48 3.3 1
Adrenergic receptor alpha-2
CHEMBL2093864
Ki 8.16 8.16 6.9 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
2887657 10.1021/jm00392a005 Adrenergic receptor alpha-2 3
2887657 10.1021/jm00392a005 Mus musculus 1

Data from ChEMBL 36 via Core Engine