Assay Detail
Functional
CHEMBL643923
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Alpha-2 adrenergic receptor antagonistic activity in rat vas deferens.
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Alpha 2-adrenergic agonists/antagonists: the synthesis and structure-activity relationships of a series of indolin-2-yl and tetrahydroquinolin-2-yl imidazolines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 7.75 | 8.48 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL39286 | — | — | 1 | 8.48 |
| CHEMBL288398 | — | — | 1 | 7.02 |
| CHEMBL288337 | — | — | 1 | - |
| CHEMBL41223 | — | — | 1 | - |
| CHEMBL41803 | — | — | 1 | - |
| CHEMBL41171 | — | — | 1 | - |
| CHEMBL41305 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL39286 | — | IC50 | = | 3.29 | nM | 8.48 |
| CHEMBL288398 | — | IC50 | = | 94.8 | nM | 7.02 |
| CHEMBL288337 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL41223 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL41803 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL41171 | — | IC50 | > | 300.0 | nM | - |
| CHEMBL41305 | — | IC50 | > | 1000.0 | nM | - |