Compound Detail
CHEMBL3948448
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CCOc1cc(C(=O)NC2CC2)cc(-c2cccc(-c3cc(NC(=O)Nc4c(Cl)cncc4Cl)c(=O)n(CC)n3)c2)c1
Basic Information
| ChEMBL ID | CHEMBL3948448 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | JFHRDTICJOZJOB-UHFFFAOYSA-N |
3
Targets
3
Activities
1
Assay Types
0
PK Parameters
6
Publications
0
Known Names
Molecular Properties
607.5
MW (Da)
6.23
ALogP
7
HBA
3
HBD
127.2
PSA (Ų)
0.21
QED
2
Ro5 Violations
9
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 3 meas. best 9.62
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Unchecked CHEMBL612545 | IC50 | 9.62 | 9.62 | 0.2 | 1 |
| 3',5'-cyclic-AMP phosphodiesterase 4B CHEMBL275 | IC50 | 9.51 | 9.51 | 0.3 | 1 |
| Adenosine receptor A1 CHEMBL226 | IC50 | 7.23 | 7.23 | 59.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Unchecked | IC50 | = | 0.24 | nM | 9.62 | Inhibition of PDE4 in PBMC (unknown origin) assessed as reduction in LPS-induced... | 27933955 |
| 3',5'-cyclic-AMP phosphodiesterase 4B | IC50 | = | 0.31 | nM | 9.51 | Inhibition of human recombinant PDE4B1 assessed as reduction in [3H]cAMP hydroly... | 27933955 |
| Adenosine receptor A1 | IC50 | = | 59.0 | nM | 7.23 | Antagonist activity at adenosine A1 receptor (unknown origin) | 27933955 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 27933955 | 10.1021/acs.jmedchem.6b00829 | Unchecked | 2 |
| 27933955 | 10.1021/acs.jmedchem.6b00829 | Rattus norvegicus | 2 |
| 27933955 | 10.1021/acs.jmedchem.6b00829 | Adenosine receptor A2b | 1 |
| 27933955 | 10.1021/acs.jmedchem.6b00829 | Adenosine receptor A2a | 1 |
| 27933955 | 10.1021/acs.jmedchem.6b00829 | Adenosine receptor A1 | 1 |
| 27933955 | 10.1021/acs.jmedchem.6b00829 | 3',5'-cyclic-AMP phosphodiesterase 4B | 1 |
Data from ChEMBL 36 via Core Engine