Compound Detail
CHEMBL3961713
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Basic Information
| ChEMBL ID | CHEMBL3961713 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | IYYHXVQQUUTOGY-DLBZAZTESA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
340.4
MW (Da)
2.44
ALogP
5
HBA
3
HBD
103.3
PSA (Ų)
0.75
QED
0
Ro5 Violations
6
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 8.05
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Tyrosine-protein kinase SYK CHEMBL2599 | IC50 | 8.05 | 8.05 | 9.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Tyrosine-protein kinase SYK | IC50 | = | 9.0 | nM | 8.05 | Inhibition of GST-tagged full length human SYK (1 to 635 end residues) expressed... | 27994755 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 27994755 | 10.1021/acsmedchemlett.6b00353 | Tyrosine-protein kinase SYK | 1 |
| 27994755 | 10.1021/acsmedchemlett.6b00353 | Salmonella typhimurium | 1 |
| 27994755 | 10.1021/acsmedchemlett.6b00353 | NON-PROTEIN TARGET | 1 |
Data from ChEMBL 36 via Core Engine