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Compound Detail

CHEMBL3969756

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Cc1cc2ccc(OCCCCN3CCN(c4cccc5sccc45)CC3)cc2[nH]c1=O

Basic Information

ChEMBL ID CHEMBL3969756
Phase Preclinical
Structure Type MOL
InChI Key PHLDMSHQFGMHOE-UHFFFAOYSA-N
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
0
Publications
0
Known Names

Molecular Properties

447.6
MW (Da)
5.03
ALogP
5
HBA
1
HBD
48.6
PSA (Ų)
0.40
QED
1
Ro5 Violations
7
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C26H29N3O2S
MW 447.60
Aromatic Rings 4
Heavy Atoms 32
NP-Likeness -1.54

Activity Summary

Ki 1 meas. best 9.1

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
D(2) dopamine receptor
CHEMBL339
Ki 9.1 9.1 0.8 1

Activity Data Samples

Top measurements by pChEMBL value

Target Type Rel. Value Units pChEMBL Assay PubMed
D(2) dopamine receptor Ki = 0.8 nM 9.1 Dopamine D2 Receptor Binding Assay: The assay was performed according to the met... -

Data from ChEMBL 36 via Core Engine