Compound Detail
CHEMBL3972739
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Basic Information
| ChEMBL ID | CHEMBL3972739 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | GESXVLPMSHUKFN-VIFPVBQESA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
311.4
MW (Da)
1.75
ALogP
6
HBA
3
HBD
120.1
PSA (Ų)
0.66
QED
0
Ro5 Violations
5
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 6.28
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Tyrosine-protein kinase SYK CHEMBL2599 | IC50 | 6.28 | 6.28 | 530.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Tyrosine-protein kinase SYK | IC50 | = | 530.0 | nM | 6.28 | Inhibition of GST-tagged full length human SYK (1 to 635 end residues) expressed... | 27994755 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 27994755 | 10.1021/acsmedchemlett.6b00353 | Tyrosine-protein kinase SYK | 1 |
| 27994755 | 10.1021/acsmedchemlett.6b00353 | Salmonella typhimurium | 1 |
| 27994755 | 10.1021/acsmedchemlett.6b00353 | NON-PROTEIN TARGET | 1 |
Data from ChEMBL 36 via Core Engine