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Compound Detail

CHEMBL3973659

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Cc1cc2ccc1[C@@H](CF)COC(=O)Nc1ccc(S(=O)(=O)C3CC3)c(c1)CN(C)C(=O)[C@@H]2Nc1ccc2c(N)nccc2c1

Basic Information

ChEMBL ID CHEMBL3973659
Phase Preclinical
Structure Type MOL
InChI Key TWGFDRIEILGDIV-YUDQIZAISA-N
1
Targets
2
Activities
1
Assay Types
0
PK Parameters
0
Publications
0
Known Names

Molecular Properties

631.7
MW (Da)
5.49
ALogP
8
HBA
3
HBD
143.7
PSA (Ų)
0.26
QED
2
Ro5 Violations
5
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C33H34FN5O5S
MW 631.73
Aromatic Rings 4
Heavy Atoms 45
NP-Likeness -0.21

Activity Summary

Ki 2 meas. best 9.55

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Coagulation factor VII
CHEMBL3991
Ki 9.55 8.125 0.3 2

Activity Data Samples

Top measurements by pChEMBL value

Data from ChEMBL 36 via Core Engine