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Compound Detail

CHEMBL4059695

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O=c1[nH]c(-c2cccc(O)c2)cn2c(=O)n(-c3ccccc3)nc12

Basic Information

ChEMBL ID CHEMBL4059695
Phase Preclinical
Structure Type MOL
InChI Key AHVNOYSSTVMABS-UHFFFAOYSA-N
3
Targets
3
Activities
1
Assay Types
0
PK Parameters
4
Publications
0
Known Names

Molecular Properties

320.3
MW (Da)
1.55
ALogP
6
HBA
2
HBD
92.4
PSA (Ų)
0.59
QED
0
Ro5 Violations
2
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C17H12N4O3
MW 320.31
Aromatic Rings 4
Heavy Atoms 24
NP-Likeness -0.71

Activity Summary

Ki 3 meas. best 6.16

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Adenosine receptor A1
CHEMBL226
Ki 6.16 6.16 698.0 1
Adenosine receptor A3
CHEMBL256
Ki 5.98 5.98 1054.0 1
Adenosine receptor A2a
CHEMBL251
Ki 5.39 5.39 4066.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
28590753 10.1021/acs.jmedchem.7b00457 Adenosine receptor A2a 1
28590753 10.1021/acs.jmedchem.7b00457 Adenosine receptor A1 1
28590753 10.1021/acs.jmedchem.7b00457 Adenosine receptor A3 1
28590753 10.1021/acs.jmedchem.7b00457 Adenosine receptor A2b 1

Data from ChEMBL 36 via Core Engine