Compound Detail
CHEMBL4078459
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
CCS(=O)(=O)Nc1ccc(Oc2ccc(F)cc2F)c(-c2cn(C)c(=O)cc2OCC(F)(F)F)c1
Basic Information
| ChEMBL ID | CHEMBL4078459 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | QWMNIEYXRHWCEB-UHFFFAOYSA-N |
2
Targets
3
Activities
2
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
518.5
MW (Da)
4.83
ALogP
6
HBA
1
HBD
86.6
PSA (Ų)
0.43
QED
1
Ro5 Violations
8
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 2 meas. best 7.0
Ki 1 meas. best 7.66
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Bromodomain-containing protein 4 CHEMBL1163125 | Ki | 7.66 | 7.66 | 22.0 | 1 |
| Bromodomain-containing protein 4 CHEMBL1163125 | EC50 | 7.0 | 7.0 | 100.0 | 1 |
| MX1 CHEMBL613704 | EC50 | 6.92 | 6.92 | 120.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Bromodomain-containing protein 4 | Ki | = | 22.0 | nM | 7.66 | Inhibition of human N-terminal His6-tagged BRD4 BD1-BD2 (57 to 550 residues) exp... | 28368119 |
| Bromodomain-containing protein 4 | EC50 | = | 100.0 | nM | 7.0 | Inhibition of BRD4 in human NCI-H1299 cells after 24 hrs by Bright-Glo luciferas... | 28368119 |
| MX1 | EC50 | = | 120.0 | nM | 6.92 | Antiproliferative activity against human MX1 cells after 72 hrs by Cell Titer Gl... | 28368119 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 28368119 | 10.1021/acs.jmedchem.7b00017 | Bromodomain-containing protein 4 | 2 |
| 28368119 | 10.1021/acs.jmedchem.7b00017 | MX1 | 1 |
| 28368119 | 10.1021/acs.jmedchem.7b00017 | No relevant target | 1 |
Data from ChEMBL 36 via Core Engine