Compound Detail
CHEMBL4094598
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Basic Information
| ChEMBL ID | CHEMBL4094598 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | XGPVMONDYJQSER-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
356.4
MW (Da)
3.37
ALogP
5
HBA
2
HBD
70.2
PSA (Ų)
0.66
QED
0
Ro5 Violations
6
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 4.6
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| PRMT5/MEP50 complex CHEMBL3137261 | IC50 | 4.6 | 4.6 | 25000.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| PRMT5/MEP50 complex | IC50 | = | 25000.0 | nM | 4.6 | Inhibition of recombinant human N-terminal FLAG-tagged PRMT5 (2 to end residues)... | 28650658 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 28650658 | 10.1021/acs.jmedchem.7b00587 | PRMT5/MEP50 complex | 1 |
Data from ChEMBL 36 via Core Engine