Compound Detail
CHEMBL409762
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CC[C@H](C)[C@H](N)C(=O)N[C@H]1CCC(=O)NC[C@@H](C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc2ccc(O)cc2)C(N)=O)NC(=O)[C@@H]2CCCN2C(=O)[C@H](NC(=O)[C@@H](N)[C@@H](C)CC)CCC(=O)NC[C@H](C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc2ccc(O)cc2)C(N)=O)NC(=O)[C@@H]2CCCN2C1=O
Basic Information
| ChEMBL ID | CHEMBL409762 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | RJRBRCCJETZJLT-VHUVHYDGSA-N |
1
Targets
4
Activities
2
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
2352.8
MW (Da)
Drug Information
| Molecule Type | Protein |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 2 meas. best 8.26
Ki 2 meas. best 8.89
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Neuropeptide Y receptor type 4 CHEMBL4877 | Ki | 8.89 | 8.845 | 1.3 | 2 |
| Neuropeptide Y receptor type 4 CHEMBL4877 | EC50 | 8.26 | 8.165 | 5.5 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Neuropeptide Y receptor type 4 | Ki | = | 1.3 | nM | 8.89 | Displacement of [3H]18 from human NPY Y4 receptor expressed in CHO cells co-expr... | 27223253 |
| Neuropeptide Y receptor type 4 | Ki | = | 1.6 | nM | 8.8 | Displacement of [3H](2R,7R)-10 from human NPY Y4 receptor expressed in CHO cells... | 27223253 |
| Neuropeptide Y receptor type 4 | EC50 | = | 5.5 | nM | 8.26 | Agonist activity at human NPY Y4 receptor expressed in HEK293 cells co-expressin... | 27223253 |
| Neuropeptide Y receptor type 4 | EC50 | = | 8.5 | nM | 8.07 | Agonist activity at human NPY Y4 receptor expressed in CHO cells co-expressing G... | 27223253 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 27223253 | 10.1021/acs.jmedchem.6b00309 | Neuropeptide Y receptor type 4 | 6 |
Data from ChEMBL 36 via Core Engine