Assay Detail
Functional
CHEMBL4478045
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at human NPY Y4 receptor expressed in CHO cells co-expressing Gqi5-mtAEQ assessed as induction of calcium mobilization by aequorin luminescence assay
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
High Affinity Agonists of the Neuropeptide Y (NPY) Y4 Receptor Derived from the C-Terminal Pentapeptide of Human Pancreatic Polypeptide (hPP): Synthesis, Stereochemical Discrimination, and Radiolabeling.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 13 | 7.59 | 8.19 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3787712 | — | — | 1 | 8.19 |
| CHEMBL4456247 | — | — | 1 | 8.16 |
| CHEMBL409762 | — | — | 1 | 8.07 |
| CHEMBL4540843 | PANCREATIC POLYPEPTIDE | 2.0 | 1 | 8.01 |
| CHEMBL3787713 | — | — | 1 | 7.89 |
| CHEMBL4522438 | — | — | 1 | 7.85 |
| CHEMBL4475071 | — | — | 1 | 7.75 |
| CHEMBL3787766 | — | — | 1 | 7.31 |
| CHEMBL4549208 | — | — | 1 | 7.23 |
| CHEMBL4581256 | — | — | 1 | 6.54 |
| CHEMBL4533775 | — | — | 1 | 6.51 |
| CHEMBL4581302 | — | — | 1 | - |
| CHEMBL4576579 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3787712 | — | EC50 | = | 6.4 | nM | 8.19 |
| CHEMBL4456247 | — | EC50 | = | 6.9 | nM | 8.16 |
| CHEMBL409762 | — | EC50 | = | 8.5 | nM | 8.07 |
| CHEMBL4540843 | PANCREATIC POLYPEPTIDE | EC50 | = | 9.7 | nM | 8.01 |
| CHEMBL3787713 | — | EC50 | = | 13.0 | nM | 7.89 |
| CHEMBL4522438 | — | EC50 | = | 14.0 | nM | 7.85 |
| CHEMBL4475071 | — | EC50 | = | 18.0 | nM | 7.75 |
| CHEMBL3787766 | — | EC50 | = | 49.0 | nM | 7.31 |
| CHEMBL4549208 | — | EC50 | = | 59.0 | nM | 7.23 |
| CHEMBL4581256 | — | EC50 | = | 290.0 | nM | 6.54 |
| CHEMBL4533775 | — | EC50 | = | 310.0 | nM | 6.51 |
| CHEMBL4581302 | — | EC50 | > | 3000.0 | nM | - |
| CHEMBL4576579 | — | EC50 | > | 3000.0 | nM | - |