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Compound Detail

CHEMBL4108610

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Cc1cc2cc(C)c1CC(O)CC(=O)Nc1ccc(S(=O)(=O)C3CC3)c(c1)CN(C)C(=O)[C@@H]2Nc1ccc2c(N)ncc(F)c2c1

Basic Information

ChEMBL ID CHEMBL4108610
Phase Preclinical
Structure Type MOL
InChI Key IIYJLFSUECBOOJ-AJLMHGPESA-N
1
Targets
2
Activities
1
Assay Types
0
PK Parameters
0
Publications
0
Known Names

Molecular Properties

645.8
MW (Da)
4.57
ALogP
8
HBA
4
HBD
154.7
PSA (Ų)
0.25
QED
1
Ro5 Violations
4
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C34H36FN5O5S
MW 645.76
Aromatic Rings 4
Heavy Atoms 46
NP-Likeness -0.32

Activity Summary

Ki 2 meas. best 8.64

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Coagulation factor VII
CHEMBL3991
Ki 8.64 7.215 2.3 2

Activity Data Samples

Top measurements by pChEMBL value

Data from ChEMBL 36 via Core Engine