Compound Detail
CHEMBL4109262
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Basic Information
| ChEMBL ID | CHEMBL4109262 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | RODIOQSCTKCZKO-BYHBIXDJSA-N |
1
Targets
3
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
388.4
MW (Da)
2.64
ALogP
6
HBA
2
HBD
107.2
PSA (Ų)
0.66
QED
0
Ro5 Violations
2
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 3 meas. best 9.54
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Mitogen-activated protein kinase kinase kinase 14 CHEMBL5888 | Ki | 9.54 | 8.13 | 0.3 | 3 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Mitogen-activated protein kinase kinase kinase 14 | Ki | = | 0.29 | nM | 9.54 | Inhibition Assay: The ability of the nuclear factor-kappa B (NF-kB)-inducing kin... | - |
| Mitogen-activated protein kinase kinase kinase 14 | Ki | = | 0.9 | nM | 9.05 | Inhibition of NIK (unknown origin) using ATP as substrate by transcreener ADP as... | 31531194 |
| Mitogen-activated protein kinase kinase kinase 14 | Ki | = | 1600.0 | nM | 5.8 | Inhibition Assay: The ability of the nuclear factor-kappa B (NF-kB)-inducing kin... | - |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 31531194 | 10.1021/acsmedchemlett.8b00658 | Serine/threonine-protein kinase D1 | 1 |
| 31531194 | 10.1021/acsmedchemlett.8b00658 | Mitogen-activated protein kinase kinase kinase 14 | 1 |
| 31531194 | 10.1021/acsmedchemlett.8b00658 | Unchecked | 1 |
Data from ChEMBL 36 via Core Engine