Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL4307635

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of NIK (unknown origin) using ATP as substrate by transcreener ADP assay based fluorescence correlation spectroscopic analysis
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Mitogen-activated protein kinase kinase kinase 14 (CHEMBL5888)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Structure Based Design of Potent Selective Inhibitors of Protein Kinase D1 (PKD1).
Feng JA, Lee P, Alaoui MH, Barrett K, Castanedo G, Godemann R, McEwan P, Wang X, Wu P, Zhang Y, Harris SF, Staben ST.
ACS Med Chem Lett (2019) 10 : 1260 -1265
PubMed 31531194 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 16 8.25 9.80

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4524153 1 9.80
CHEMBL4113471 1 9.10
CHEMBL4109262 1 9.05
CHEMBL4073390 1 9.00
CHEMBL4111969 1 8.77
CHEMBL4115120 1 8.51
CHEMBL3692392 1 8.00
CHEMBL3692489 1 7.85
CHEMBL3978002 1 6.24
CHEMBL4546659 1 6.20
CHEMBL3896516 1 -
CHEMBL3957252 1 -
CHEMBL4461552 1 -
CHEMBL4444206 1 -
CHEMBL4517096 1 -
CHEMBL3941082 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4524153 Ki = 0.16 nM 9.80
CHEMBL4113471 Ki = 0.8 nM 9.10
CHEMBL4109262 Ki = 0.9 nM 9.05
CHEMBL4073390 Ki = 1.0 nM 9.00
CHEMBL4111969 Ki = 1.7 nM 8.77
CHEMBL4115120 Ki = 3.1 nM 8.51
CHEMBL3692392 Ki = 10.0 nM 8.00
CHEMBL3692489 Ki = 14.0 nM 7.85
CHEMBL3978002 Ki = 582.0 nM 6.24
CHEMBL4546659 Ki = 634.0 nM 6.20
CHEMBL3896516 Ki > 250.0 nM -
CHEMBL3957252 Ki > 1250.0 nM -
CHEMBL4461552 Ki > 1250.0 nM -
CHEMBL4444206 Ki > 1250.0 nM -
CHEMBL4517096 Ki > 1250.0 nM -
CHEMBL3941082 Ki >= 1250.0 nM -