Compound Detail
CHEMBL4115462
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Basic Information
| ChEMBL ID | CHEMBL4115462 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | CBQXGRKXMPLXLY-UCWRFOARSA-N |
3
Targets
3
Activities
1
Assay Types
0
PK Parameters
0
Publications
0
Known Names
Molecular Properties
395.3
MW (Da)
0.36
ALogP
7
HBA
5
HBD
176.6
PSA (Ų)
0.35
QED
0
Ro5 Violations
10
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 3 meas. best 7.1
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Metabotropic glutamate receptor 4 CHEMBL2787 | EC50 | 7.1 | 7.1 | 80.0 | 1 |
| Metabotropic glutamate receptor 7 CHEMBL3879 | EC50 | 5.46 | 5.46 | 3500.0 | 1 |
| Metabotropic glutamate receptor 8 CHEMBL2718 | EC50 | 4.99 | 4.99 | 10300.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Metabotropic glutamate receptor 4 | EC50 | = | 80.0 | nM | 7.1 | Pharmacological Assay: Metabotropic glutamate receptors were transiently transfe... | - |
| Metabotropic glutamate receptor 7 | EC50 | = | 3500.0 | nM | 5.46 | Pharmacological Assay: Metabotropic glutamate receptors were transiently transfe... | - |
| Metabotropic glutamate receptor 8 | EC50 | = | 10300.0 | nM | 4.99 | Pharmacological Assay: Metabotropic glutamate receptors were transiently transfe... | - |
Data from ChEMBL 36 via Core Engine