Compound Detail
CHEMBL416152
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Basic Information
| ChEMBL ID | CHEMBL416152 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | ZBCGBIZQNMVMPC-UHFFFAOYSA-N |
1
Targets
3
Activities
2
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
187.2
MW (Da)
2.02
ALogP
3
HBA
0
HBD
39.2
PSA (Ų)
0.64
QED
0
Ro5 Violations
1
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 2 meas. best 4.88
IC50 1 meas. best 4.88
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| GABA-A receptor; anion channel CHEMBL1907607 | IC50 | 4.88 | 4.88 | 13200.0 | 1 |
| GABA-A receptor; anion channel CHEMBL1907607 | Ki | 4.88 | 4.88 | 13200.0 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| GABA-A receptor; anion channel | IC50 | = | 13200.0 | nM | 4.88 | In vitro inhibition of binding to the benzodiazepine receptor in rat cerebral co... | 2842507 |
| GABA-A receptor; anion channel | Ki | = | 13200.0 | nM | 4.88 | In vitro inhibition of [3H]diazepam binding to benzodiazepine receptor in rat ce... | 6127411 |
| GABA-A receptor; anion channel | Ki | = | 13200.0 | nM | 4.88 | In vitro inhibition of [3H]diazepam binding to rat cerebral cortical membrane be... | 6325688 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 6127411 | 10.1021/jm00351a015 | GABA-A receptor; anion channel | 1 |
| 2842507 | 10.1021/jm00117a029 | GABA-A receptor; anion channel | 1 |
| 6325688 | 10.1021/jm00371a002 | GABA-A receptor; anion channel | 1 |
Data from ChEMBL 36 via Core Engine