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Compound Detail

CHEMBL417565

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O=C(c1ccco1)N1CCN(c2ccc(=O)n(CCCCCN3CCN(c4ccccc4Cl)CC3)n2)CC1

Basic Information

ChEMBL ID CHEMBL417565
Phase Preclinical
Structure Type MOL
InChI Key OBOGYKVWLPQVDO-UHFFFAOYSA-N
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names

Molecular Properties

539.1
MW (Da)
3.44
ALogP
8
HBA
0
HBD
78.1
PSA (Ų)
0.39
QED
1
Ro5 Violations
9
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C28H35ClN6O3
MW 539.08
Aromatic Rings 3
Heavy Atoms 38
NP-Likeness -1.99

Activity Summary

Ki 2 meas. best 7.88

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Adrenergic receptor alpha-1
CHEMBL1907610
Ki 7.88 7.88 13.3 1
Adrenergic receptor alpha-2
CHEMBL2093864
Ki 6.98 6.98 105.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
11405649 10.1021/jm010821u Adrenergic receptor alpha-2 2
11405649 10.1021/jm010821u Adrenergic receptor alpha-1 1

Data from ChEMBL 36 via Core Engine