Compound Detail
CHEMBL425008
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Basic Information
| ChEMBL ID | CHEMBL425008 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | NRKFYDQWSIYFGJ-PCODVIEZSA-N |
2
Targets
3
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
359.4
MW (Da)
3.67
ALogP
3
HBA
1
HBD
32.7
PSA (Ų)
0.90
QED
0
Ro5 Violations
4
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 3 meas. best 8.09
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Sodium-dependent dopamine transporter CHEMBL338 | IC50 | 8.09 | 8.005 | 8.1 | 2 |
| Sodium-dependent serotonin transporter CHEMBL313 | IC50 | 4.96 | 4.96 | 11000.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Sodium-dependent dopamine transporter | IC50 | = | 8.1 | nM | 8.09 | Inhibition of [3H]dopamine uptake into rat striatal synaptosomes | 15857139 |
| Sodium-dependent dopamine transporter | IC50 | = | 12.0 | nM | 7.92 | Displacement of [3H]WIN-35428 from Dopamine transporter of rat caudate putamen | 15857139 |
| Sodium-dependent serotonin transporter | IC50 | = | 11000.0 | nM | 4.96 | Displacement of [3H]paroxetine from Serotonin transporter of rat caudate putamen | 15857139 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 15857139 | 10.1021/jm0490235 | Sodium-dependent dopamine transporter | 2 |
| 15857139 | 10.1021/jm0490235 | Sodium-dependent serotonin transporter | 1 |
Data from ChEMBL 36 via Core Engine