Compound Detail
CHEMBL43406
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Basic Information
| ChEMBL ID | CHEMBL43406 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | XQRDAEMFUZSXOO-UHFFFAOYSA-N |
1
Targets
3
Activities
1
Assay Types
0
PK Parameters
7
Publications
0
Known Names
Molecular Properties
255.3
MW (Da)
2.59
ALogP
4
HBA
1
HBD
60.0
PSA (Ų)
0.78
QED
0
Ro5 Violations
3
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 3 meas. best 4.24
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| cGMP-dependent 3',5'-cyclic phosphodiesterase CHEMBL2652 | IC50 | 4.24 | 4.24 | 57000.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| cGMP-dependent 3',5'-cyclic phosphodiesterase | IC50 | = | 57000.0 | nM | 4.24 | Inhibition of cyclic GMP sensitive phosphodiesterase PDE 2 of guinea pig ventric... | 2985781 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 4009593 | 10.1021/jm00383a006 | Felis catus | 4 |
| 4009593 | 10.1021/jm00383a006 | Canis familiaris | 3 |
| 2165165 | 10.1021/jm00170a030 | Cavia porcellus | 1 |
| 3397997 | 10.1021/jm00403a018 | Felis catus | 1 |
| 2985781 | 10.1021/jm50001a001 | Phosphodiesterase 1 | 1 |
| 2985781 | 10.1021/jm50001a001 | cGMP-dependent 3',5'-cyclic phosphodiesterase | 1 |
| 2985781 | 10.1021/jm50001a001 | Phosphodiesterase 3 | 1 |
Data from ChEMBL 36 via Core Engine