Assay Detail
Binding
CHEMBL759916
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of cyclic GMP sensitive phosphodiesterase PDE 2 of guinea pig ventricle
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
cGMP-dependent 3',5'-cyclic phosphodiesterase (CHEMBL2652) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
A new generation of phosphodiesterase inhibitors: multiple molecular forms of phosphodiesterase and the potential for drug selectivity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 4.82 | 5.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL932 | DIPYRIDAMOLE | 4.0 | 1 | 5.40 |
| CHEMBL43406 | — | — | 1 | 4.24 |
| CHEMBL249856 | ENOXIMONE | 3.0 | 1 | - |
| CHEMBL286020 | SULMAZOLE | 2.0 | 1 | - |
| CHEMBL12831 | IMAZODAN | 2.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL932 | DIPYRIDAMOLE | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL43406 | — | IC50 | = | 57000.0 | nM | 4.24 |
| CHEMBL249856 | ENOXIMONE | IC50 | = | 520000.0 | nM | - |
| CHEMBL286020 | SULMAZOLE | IC50 | = | 200000.0 | nM | - |
| CHEMBL12831 | IMAZODAN | IC50 | = | 760000.0 | nM | - |