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Compound Detail

CHEMBL439867

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O=C(O[C@H]1CN2CCC1CC2)N1CCc2ccccc2C1c1ccccc1

Basic Information

ChEMBL ID CHEMBL439867
Phase Preclinical
Structure Type MOL
InChI Key FBOUYBDGKBSUES-HMTLIYDFSA-N
3
Targets
3
Activities
1
Assay Types
0
PK Parameters
4
Publications
0
Known Names

Molecular Properties

362.5
MW (Da)
3.86
ALogP
3
HBA
0
HBD
32.8
PSA (Ų)
0.81
QED
0
Ro5 Violations
2
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

Natural Product First in Class Prodrug

Extended Properties

Molecular Formula C23H26N2O2
MW 362.47
Aromatic Rings 2
Heavy Atoms 27
NP-Likeness -0.06

Activity Summary

Ki 3 meas. best 8.85

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Muscarinic acetylcholine receptor M1
CHEMBL276
Ki 8.85 8.85 1.4 1
Muscarinic acetylcholine receptor M3
CHEMBL320
Ki 8.27 8.27 5.4 1
Muscarinic acetylcholine receptor M2
CHEMBL309
Ki 7.55 7.55 28.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
16220976 10.1021/jm050099q Muscarinic acetylcholine receptor M1 1
16220976 10.1021/jm050099q Muscarinic acetylcholine receptor M2 1
16220976 10.1021/jm050099q Muscarinic acetylcholine receptor M3 1
16220976 10.1021/jm050099q Muscarinic receptor M2 and M3 1

Data from ChEMBL 36 via Core Engine