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Compound Detail

CHEMBL443429

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CC(=O)NCCc1c[nH]c2ccc([N+](=O)[O-])cc12

Basic Information

ChEMBL ID CHEMBL443429
Phase Preclinical
Structure Type MOL
InChI Key PKDUVHDAPLRJMS-UHFFFAOYSA-N
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names

Molecular Properties

247.2
MW (Da)
1.75
ALogP
3
HBA
2
HBD
88.0
PSA (Ų)
0.64
QED
0
Ro5 Violations
4
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

Natural Product First in Class Prodrug

Extended Properties

Molecular Formula C12H13N3O3
MW 247.25
Aromatic Rings 2
Heavy Atoms 18
NP-Likeness -1.14

Activity Summary

IC50 1 meas. best 7.38

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Ribosyldihydronicotinamide dehydrogenase [quinone]
CHEMBL3959
IC50 7.38 7.38 41.7 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
18400335 10.1016/j.ejmech.2008.02.012 Ribosyldihydronicotinamide dehydrogenase [quinone] 1

Data from ChEMBL 36 via Core Engine