Assay Detail
Binding
CHEMBL1016924
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [125I]iodomelatonin from MT3/QR2 melatonin binding site expressed in CHO cells
39
Total Activities
39
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | CHO |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Target
Ribosyldihydronicotinamide dehydrogenase [quinone] (CHEMBL3959) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
A novel quantitative structure-activity relationship method to predict the affinities of MT3 melatonin binding site.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 39 | 7.90 | 10.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL300056 | — | — | 1 | 10.05 |
| CHEMBL300728 | — | — | 1 | 9.89 |
| CHEMBL52559 | — | — | 1 | 9.70 |
| CHEMBL511675 | — | — | 1 | 9.52 |
| CHEMBL53622 | — | — | 1 | 9.51 |
| CHEMBL300195 | — | — | 1 | 8.92 |
| CHEMBL33700 | — | — | 1 | 8.55 |
| CHEMBL457126 | — | — | 1 | 8.52 |
| CHEMBL465378 | — | — | 1 | 8.11 |
| CHEMBL457992 | — | — | 1 | 8.04 |
| CHEMBL457541 | — | — | 1 | 7.96 |
| CHEMBL493424 | — | — | 1 | 7.96 |
| CHEMBL455339 | — | — | 1 | 7.92 |
| CHEMBL495399 | — | — | 1 | 7.85 |
| CHEMBL457539 | — | — | 1 | 7.85 |
| CHEMBL446329 | — | — | 1 | 7.80 |
| CHEMBL456727 | — | — | 1 | 7.74 |
| CHEMBL494566 | — | — | 1 | 7.74 |
| CHEMBL458209 | — | — | 1 | 7.68 |
| CHEMBL521826 | — | — | 1 | 7.64 |
| CHEMBL456691 | — | — | 1 | 7.62 |
| CHEMBL443636 | — | — | 1 | 7.55 |
| CHEMBL34348 | — | — | 1 | 7.54 |
| CHEMBL457763 | — | — | 1 | 7.49 |
| CHEMBL456646 | — | — | 1 | 7.43 |
| CHEMBL443429 | — | — | 1 | 7.38 |
| CHEMBL37703 | — | — | 1 | 7.36 |
| CHEMBL457764 | — | — | 1 | 7.29 |
| CHEMBL467573 | — | — | 1 | 7.28 |
| CHEMBL457540 | — | — | 1 | 7.27 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL300056 | — | IC50 | = | 0.08913 | nM | 10.05 |
| CHEMBL300728 | — | IC50 | = | 0.1288 | nM | 9.89 |
| CHEMBL52559 | — | IC50 | = | 0.1995 | nM | 9.70 |
| CHEMBL511675 | — | IC50 | = | 0.302 | nM | 9.52 |
| CHEMBL53622 | — | IC50 | = | 0.309 | nM | 9.51 |
| CHEMBL300195 | — | IC50 | = | 1.202 | nM | 8.92 |
| CHEMBL33700 | — | IC50 | = | 2.818 | nM | 8.55 |
| CHEMBL457126 | — | IC50 | = | 3.02 | nM | 8.52 |
| CHEMBL465378 | — | IC50 | = | 7.762 | nM | 8.11 |
| CHEMBL457992 | — | IC50 | = | 9.12 | nM | 8.04 |
| CHEMBL493424 | — | IC50 | = | 10.96 | nM | 7.96 |
| CHEMBL457541 | — | IC50 | = | 10.96 | nM | 7.96 |
| CHEMBL455339 | — | IC50 | = | 12.02 | nM | 7.92 |
| CHEMBL495399 | — | IC50 | = | 14.13 | nM | 7.85 |
| CHEMBL457539 | — | IC50 | = | 14.13 | nM | 7.85 |
| CHEMBL446329 | — | IC50 | = | 15.85 | nM | 7.80 |
| CHEMBL456727 | — | IC50 | = | 18.2 | nM | 7.74 |
| CHEMBL494566 | — | IC50 | = | 18.2 | nM | 7.74 |
| CHEMBL458209 | — | IC50 | = | 20.89 | nM | 7.68 |
| CHEMBL521826 | — | IC50 | = | 22.91 | nM | 7.64 |
| CHEMBL456691 | — | IC50 | = | 23.99 | nM | 7.62 |
| CHEMBL443636 | — | IC50 | = | 28.18 | nM | 7.55 |
| CHEMBL34348 | — | IC50 | = | 28.84 | nM | 7.54 |
| CHEMBL457763 | — | IC50 | = | 32.36 | nM | 7.49 |
| CHEMBL456646 | — | IC50 | = | 37.15 | nM | 7.43 |
| CHEMBL443429 | — | IC50 | = | 41.69 | nM | 7.38 |
| CHEMBL37703 | — | IC50 | = | 43.65 | nM | 7.36 |
| CHEMBL457764 | — | IC50 | = | 51.29 | nM | 7.29 |
| CHEMBL467573 | — | IC50 | = | 52.48 | nM | 7.28 |
| CHEMBL457540 | — | IC50 | = | 53.7 | nM | 7.27 |
| CHEMBL521827 | — | IC50 | = | 56.23 | nM | 7.25 |
| CHEMBL504585 | — | IC50 | = | 57.54 | nM | 7.24 |
| CHEMBL511361 | — | IC50 | = | 61.66 | nM | 7.21 |
| CHEMBL457533 | — | IC50 | = | 61.66 | nM | 7.21 |
| CHEMBL45 | MELATONIN | IC50 | = | 64.57 | nM | 7.19 |
| CHEMBL323332 | — | IC50 | = | 64.57 | nM | 7.19 |
| CHEMBL451333 | — | IC50 | = | 67.61 | nM | 7.17 |
| CHEMBL505118 | — | IC50 | = | 67.61 | nM | 7.17 |
| CHEMBL111674 | — | IC50 | = | 70.79 | nM | 7.15 |