Compound Detail
CHEMBL4440737
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Basic Information
| ChEMBL ID | CHEMBL4440737 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | WWTZERNRABUKSV-UHFFFAOYSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
0
Publications
0
Known Names
Molecular Properties
319.4
MW (Da)
3.79
ALogP
5
HBA
2
HBD
67.2
PSA (Ų)
0.60
QED
0
Ro5 Violations
4
Rot. Bonds
Drug Information
| Molecule Type | Unknown |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 8.5
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| E3 ubiquitin-protein ligase TRIM33 CHEMBL2176772 | IC50 | 8.5 | 8.5 | 3.2 | 1 |
| Transcription intermediary factor 1-alpha CHEMBL3108638 | IC50 | 5.77 | 5.77 | 1714.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| E3 ubiquitin-protein ligase TRIM33 | IC50 | = | 3.19 | nM | 8.5 | Inhibition of recombinant TRIM33 PHD bromodomain (unknown origin) using biotinyl... | - |
| Transcription intermediary factor 1-alpha | IC50 | = | 1714.0 | nM | 5.77 | Inhibition of recombinant TRIM24 (unknown origin) using biotinylated H3 peptide ... | - |
Data from ChEMBL 36 via Core Engine