E3 ubiquitin-protein ligase TRIM33 · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-14Protein identity stays anchored to UniProt Q9UPN9. Use UniProt Q9UPN9 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt Q9UPN9 as the stable identity anchor, then attach disease evidence before program review.
E3 ubiquitin-protein ligase TRIM33
Review this target as E3 ubiquitin-protein ligase TRIM33, mapped to UniProt Q9UPN9. Sequence length is 1127 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats E3 ubiquitin-protein ligase TRIM33 as ChEMBL target CHEMBL2176772, mapped to UniProt Q9UPN9. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | E3 ubiquitin-protein ligase TRIM33 |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | Q9UPN9 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | E3 ubiquitin-protein ligase TRIM33 |
| UniProt Accession | Q9UPN9 |
| Component Type | Protein |
| Sequence Length | 1127 aa |
E3 ubiquitin-protein ligase TRIM33
Review this target as E3 ubiquitin-protein ligase TRIM33, mapped to UniProt Q9UPN9. Sequence length is 1127 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL4440737 | 8.5 | IC50 | 3.19 | Preclinical |
| CHEMBL4470967 | 7.86 | IC50 | 13.72 | Preclinical |
| CHEMBL1232461 | 6.85 | IC50 | 140.0 | Clinical |
| CHEMBL1232461 | 6.76 | Kd | 173.0 | Clinical |
| CHEMBL18620 | 6.63 | IC50 | 233.5 | Preclinical |
| CHEMBL4467793 | 6.62 | IC50 | 240.3 | Preclinical |
| CHEMBL18737 | 6.6 | IC50 | 249.8 | Preclinical |
| CHEMBL4572394 | 6.57 | IC50 | 268.9 | Preclinical |
| CHEMBL543846 | 6.55 | IC50 | 283.4 | Preclinical |
| CHEMBL108925 | 6.52 | IC50 | 299.4 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 23 | 117 | 5.1 |
| assay format | 19 | 0 | — |
| cell-based format | 5 | 0 | — |