Compound Detail
CHEMBL4443139
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Basic Information
| ChEMBL ID | CHEMBL4443139 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | NWPAIRZLGKDVNX-UHFFFAOYSA-N |
2
Targets
3
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
305.3
MW (Da)
3.49
ALogP
4
HBA
2
HBD
79.8
PSA (Ų)
0.78
QED
0
Ro5 Violations
3
Rot. Bonds
Drug Information
| Molecule Type | Unknown |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 3 meas. best 5.64
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| NT-3 growth factor receptor CHEMBL5608 | IC50 | 5.64 | 5.64 | 2300.0 | 1 |
| High affinity nerve growth factor receptor CHEMBL2815 | IC50 | 5.4 | 5.4 | 4000.0 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| NT-3 growth factor receptor | IC50 | = | 2300.0 | nM | 5.64 | Inhibition of TRKC (unknown origin) | 30188734 |
| High affinity nerve growth factor receptor | IC50 | = | 4000.0 | nM | 5.4 | Inhibition of TRKA (unknown origin) | 30188734 |
| High affinity nerve growth factor receptor | IC50 | = | 4000.0 | nM | 5.4 | TrkA Receptor : TrkA functional activity was measured using a DiscoverX PathHunt... | - |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 30188734 | 10.1021/acs.jmedchem.8b01092 | NT-3 growth factor receptor | 1 |
| 30188734 | 10.1021/acs.jmedchem.8b01092 | High affinity nerve growth factor receptor | 1 |
Data from ChEMBL 36 via Core Engine