Assay Detail
Binding
CHEMBL4330191
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of TRKA (unknown origin)
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
High affinity nerve growth factor receptor (CHEMBL2815) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Insights into Current Tropomyosin Receptor Kinase (TRK) Inhibitors: Development and Clinical Application.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 6.97 | 9.07 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3545365 | ALTIRATINIB | 2.0 | 1 | 9.07 |
| CHEMBL3989926 | SITRAVATINIB | 3.0 | 1 | 8.30 |
| CHEMBL575448 | BMS-754807 | 2.0 | 1 | 8.15 |
| CHEMBL4468886 | — | — | 1 | 7.00 |
| CHEMBL4469569 | — | — | 1 | 5.48 |
| CHEMBL4443139 | — | — | 1 | 5.40 |
| CHEMBL4584074 | — | — | 1 | 5.39 |
| CHEMBL2172308 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3545365 | ALTIRATINIB | IC50 | = | 0.85 | nM | 9.07 |
| CHEMBL3989926 | SITRAVATINIB | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL575448 | BMS-754807 | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL4468886 | — | IC50 | = | 99.0 | nM | 7.00 |
| CHEMBL4469569 | — | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL4443139 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL4584074 | — | IC50 | = | 4100.0 | nM | 5.39 |
| CHEMBL2172308 | — | IC50 | < | 3.0 | nM | - |