Compound Detail
CHEMBL4584074
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Basic Information
| ChEMBL ID | CHEMBL4584074 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | QTGKTWMSCVUXHK-UHFFFAOYSA-N |
2
Targets
3
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
354.4
MW (Da)
5.25
ALogP
3
HBA
2
HBD
66.9
PSA (Ų)
0.53
QED
1
Ro5 Violations
3
Rot. Bonds
Drug Information
| Molecule Type | Unknown |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 3 meas. best 5.39
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| High affinity nerve growth factor receptor CHEMBL2815 | IC50 | 5.39 | 5.39 | 4100.0 | 2 |
| NT-3 growth factor receptor CHEMBL5608 | IC50 | 5.15 | 5.15 | 7100.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| High affinity nerve growth factor receptor | IC50 | = | 4100.0 | nM | 5.39 | Inhibition of TRKA (unknown origin) | 30188734 |
| High affinity nerve growth factor receptor | IC50 | = | 4100.0 | nM | 5.39 | TrkA Receptor : TrkA functional activity was measured using a DiscoverX PathHunt... | - |
| NT-3 growth factor receptor | IC50 | = | 7100.0 | nM | 5.15 | Inhibition of TRKC (unknown origin) | 30188734 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 30188734 | 10.1021/acs.jmedchem.8b01092 | NT-3 growth factor receptor | 1 |
| 30188734 | 10.1021/acs.jmedchem.8b01092 | High affinity nerve growth factor receptor | 1 |
Data from ChEMBL 36 via Core Engine