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Compound Detail

CHEMBL4445289

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CC(C)(CCc1ccccc1)NC[C@H](O)c1ccc(O)c2[nH]c(=O)ccc12

Basic Information

ChEMBL ID CHEMBL4445289
Phase Preclinical
Structure Type MOL
InChI Key XBCNZHWPHYJZGM-IBGZPJMESA-N
2
Targets
3
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names

Molecular Properties

366.5
MW (Da)
3.27
ALogP
4
HBA
4
HBD
85.3
PSA (Ų)
0.52
QED
0
Ro5 Violations
7
Rot. Bonds

Drug Information

Molecule Type Unknown
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C22H26N2O3
MW 366.46
Aromatic Rings 3
Heavy Atoms 27
NP-Likeness 0.30

Activity Summary

EC50 3 meas. best 10.68

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Beta-2 adrenergic receptor
CHEMBL210
EC50 10.68 10.68 0.0 2
Beta-1 adrenergic receptor
CHEMBL213
EC50 5.0 5.0 10000.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
30392952 10.1016/j.bmc.2018.10.043 Beta-2 adrenergic receptor 8
30392952 10.1016/j.bmc.2018.10.043 Beta-1 adrenergic receptor 1
30392952 10.1016/j.bmc.2018.10.043 Unchecked 1

Data from ChEMBL 36 via Core Engine