Compound Detail
CHEMBL4447582
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Cc1c(C#Cc2cnc3cnc(-c4ccc(N)cc4)cn23)cccc1C(=O)Nc1cc(CN2CCN(C)CC2)cc(C(C)C)c1
Basic Information
| ChEMBL ID | CHEMBL4447582 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | KDFREDAEEQQCFD-UHFFFAOYSA-N |
4
Targets
4
Activities
1
Assay Types
0
PK Parameters
9
Publications
0
Known Names
Molecular Properties
597.8
MW (Da)
5.81
ALogP
7
HBA
2
HBD
91.8
PSA (Ų)
0.19
QED
2
Ro5 Violations
6
Rot. Bonds
Drug Information
| Molecule Type | Unknown |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 4 meas. best 8.58
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| High affinity nerve growth factor receptor CHEMBL2815 | IC50 | 8.58 | 8.58 | 2.6 | 1 |
| NT-3 growth factor receptor CHEMBL5608 | IC50 | 8.53 | 8.53 | 3.0 | 1 |
| BDNF/NT-3 growth factors receptor CHEMBL4898 | IC50 | 7.98 | 7.98 | 10.5 | 1 |
| SH-SY5Y CHEMBL614910 | IC50 | 7.24 | 7.24 | 58.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| High affinity nerve growth factor receptor | IC50 | = | 2.65 | nM | 8.58 | Inhibition of recombinant human His-tagged TrkA catalytic domain (441 to 796 res... | 31271959 |
| NT-3 growth factor receptor | IC50 | = | 2.95 | nM | 8.53 | Inhibition of recombinant human His-tagged TrkC cytoplasmic domain (510 to 825 r... | 31271959 |
| BDNF/NT-3 growth factors receptor | IC50 | = | 10.47 | nM | 7.98 | Inhibition of recombinant human His-tagged TrkB catalytic domain (526 to 838 res... | 31271959 |
| SH-SY5Y | IC50 | = | 58.0 | nM | 7.24 | Antiproliferative activity against human SH-SY5Y cells transfected with TrkB (un... | 31271959 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 31271959 | 10.1016/j.ejmech.2019.06.064 | SH-SY5Y | 13 |
| 31271959 | 10.1016/j.ejmech.2019.06.064 | ADMET | 9 |
| 31271959 | 10.1016/j.ejmech.2019.06.064 | BDNF/NT-3 growth factors receptor | 6 |
| 31271959 | 10.1016/j.ejmech.2019.06.064 | High affinity nerve growth factor receptor | 1 |
| 31271959 | 10.1016/j.ejmech.2019.06.064 | NT-3 growth factor receptor | 1 |
| 31271959 | 10.1016/j.ejmech.2019.06.064 | Tyrosine-protein kinase ABL1 | 1 |
| 31271959 | 10.1016/j.ejmech.2019.06.064 | RAC-alpha serine/threonine-protein kinase | 1 |
| 31271959 | 10.1016/j.ejmech.2019.06.064 | Unchecked | 1 |
| 31271959 | 10.1016/j.ejmech.2019.06.064 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 | 1 |
Data from ChEMBL 36 via Core Engine