Compound Detail
CHEMBL4452569
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Basic Information
| ChEMBL ID | CHEMBL4452569 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | KBQLQDPQEMFGCB-UHFFFAOYSA-N |
5
Targets
5
Activities
2
Assay Types
0
PK Parameters
13
Publications
0
Known Names
Molecular Properties
355.1
MW (Da)
3.80
ALogP
2
HBA
1
HBD
33.6
PSA (Ų)
0.70
QED
0
Ro5 Violations
2
Rot. Bonds
Drug Information
| Molecule Type | Unknown |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 4 meas. best 8.4
IC50 1 meas. best 7.0
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| 5-hydroxytryptamine receptor 7 CHEMBL3155 | Ki | 8.4 | 8.4 | 4.0 | 1 |
| Cytochrome P450 3A4 CHEMBL340 | IC50 | 7.0 | 7.0 | 100.0 | 1 |
| 5-hydroxytryptamine receptor 1A CHEMBL214 | Ki | 6.23 | 6.23 | 589.0 | 1 |
| 5-hydroxytryptamine receptor 6 CHEMBL3371 | Ki | 5.54 | 5.54 | 2884.0 | 1 |
| D(2) dopamine receptor CHEMBL217 | Ki | 5.15 | 5.15 | 7080.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| 5-hydroxytryptamine receptor 7 | Ki | = | 4.0 | nM | 8.4 | Displacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HE... | 30904783 |
| Cytochrome P450 3A4 | IC50 | = | 100.0 | nM | 7.0 | Inhibition of human CYP3A4 measured after 30 mins in presence of NADPH regenerat... | 30904783 |
| 5-hydroxytryptamine receptor 1A | Ki | = | 589.0 | nM | 6.23 | Displacement of [3H]-8-OH-DPAT from human recombinant 5-HT1A receptor expressed ... | 30904783 |
| 5-hydroxytryptamine receptor 6 | Ki | = | 2884.0 | nM | 5.54 | Displacement of [3H] LSD from human recombinant 5-HT6 receptor expressed in HEK2... | 30904783 |
| D(2) dopamine receptor | Ki | = | 7080.0 | nM | 5.15 | Displacement of [3H] raclopride from human recombinant D2L receptor expressed in... | 30904783 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 30904783 | 10.1016/j.ejmech.2019.03.017 | Mus musculus | 6 |
| 30904783 | 10.1016/j.ejmech.2019.03.017 | 5-hydroxytryptamine receptor 7 | 3 |
| 30904783 | 10.1016/j.ejmech.2019.03.017 | No relevant target | 2 |
| 30904783 | 10.1016/j.ejmech.2019.03.017 | HepG2 | 1 |
| 30904783 | 10.1016/j.ejmech.2019.03.017 | HEK293 | 1 |
| 30904783 | 10.1016/j.ejmech.2019.03.017 | ADMET | 1 |
| 30904783 | 10.1016/j.ejmech.2019.03.017 | Cytochrome P450 3A4 | 1 |
| 30904783 | 10.1016/j.ejmech.2019.03.017 | ATP-dependent translocase ABCB1 | 1 |
| 30904783 | 10.1016/j.ejmech.2019.03.017 | N1E-115 | 1 |
| 30904783 | 10.1016/j.ejmech.2019.03.017 | D(2) dopamine receptor | 1 |
| 30904783 | 10.1016/j.ejmech.2019.03.017 | 5-hydroxytryptamine receptor 6 | 1 |
| 30904783 | 10.1016/j.ejmech.2019.03.017 | 5-hydroxytryptamine receptor 2A | 1 |
| 30904783 | 10.1016/j.ejmech.2019.03.017 | 5-hydroxytryptamine receptor 1A | 1 |
Data from ChEMBL 36 via Core Engine