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Compound Detail

CHEMBL4454696

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CC(C)[C@H]1CC[C@@](O)(COC(=O)/C(=C/[C@@H]2[C@@H](C(C)C)CC[C@@]3(O)COC(=O)[C@@H]23)CO)[C@@H](C(=O)O)[C@@H]1/C=C(\CO)C(=O)O[C@@]12CC[C@H](C(C)C)[C@@H](/C=C(\CO)C(=O)O)[C@@H]1C(=O)OC2

Basic Information

ChEMBL ID CHEMBL4454696
Phase Preclinical
Structure Type MOL
InChI Key VUDGRKLUMAAASW-OGFCOVEESA-N
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
12
Publications
0
Known Names

Molecular Properties

877.0
MW (Da)
2.21
ALogP
15
HBA
7
HBD
280.9
PSA (Ų)
0.07
QED
3
Ro5 Violations
16
Rot. Bonds

Drug Information

Molecule Type Unknown
Availability Unknown
Chirality Unknown

Flags

Natural Product First in Class Prodrug

Extended Properties

Molecular Formula C45H64O17
MW 876.99
Aromatic Rings 0
Heavy Atoms 62
NP-Likeness 1.26

Activity Summary

IC50 1 meas. best 5.0

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Enterococcus faecalis
CHEMBL362
IC50 5.0 5.0 10000.0 1

Activity Data Samples

Top measurements by pChEMBL value

Target Type Rel. Value Units pChEMBL Assay PubMed
Enterococcus faecalis IC50 = 10000.0 nM 5.0 Antibacterial activity against vancomycin-resistant Enterococcus faecalis AUS-RB... 31625738

Literature References

PubMed DOI Target Context # Activities
31625738 10.1021/acs.jnatprod.9b00760 Staphylococcus aureus 2
31625738 10.1021/acs.jnatprod.9b00760 Escherichia coli 2
31625738 10.1021/acs.jnatprod.9b00760 Pseudomonas aeruginosa 2
31625738 10.1021/acs.jnatprod.9b00760 Klebsiella pneumoniae 2
31625738 10.1021/acs.jnatprod.9b00760 Enterococcus faecalis 2
31625738 10.1021/acs.jnatprod.9b00760 ADMET 2
31625738 10.1021/acs.jnatprod.9b00760 SW-620 1
31625738 10.1021/acs.jnatprod.9b00760 NCI-H460 1
31625738 10.1021/acs.jnatprod.9b00760 Candida albicans 1
31625738 10.1021/acs.jnatprod.9b00760 Bacillus subtilis 1
31625738 10.1021/acs.jnatprod.9b00760 Streptococcus pyogenes 1
31625738 10.1021/acs.jnatprod.9b00760 Acinetobacter baumannii 1

Data from ChEMBL 36 via Core Engine