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Compound Detail

CHEMBL4455058

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COc1cccnc1C1CCN(C2CCCN(c3cnccn3)CC2)CC1

Basic Information

ChEMBL ID CHEMBL4455058
Phase Preclinical
Structure Type MOL
InChI Key OOCLFOYPNHPENS-UHFFFAOYSA-N
2
Targets
3
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names

Molecular Properties

367.5
MW (Da)
3.12
ALogP
6
HBA
0
HBD
54.4
PSA (Ų)
0.83
QED
0
Ro5 Violations
4
Rot. Bonds

Drug Information

Molecule Type Unknown
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C21H29N5O
MW 367.50
Aromatic Rings 2
Heavy Atoms 27
NP-Likeness -1.38

Activity Summary

EC50 3 meas. best 7.8

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Muscarinic acetylcholine receptor M4
CHEMBL1821
EC50 7.8 7.7 16.0 2
Muscarinic acetylcholine receptor M2
CHEMBL211
EC50 6.6 6.6 250.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
31223452 10.1021/acsmedchemlett.9b00106 Muscarinic acetylcholine receptor M4 4
31223452 10.1021/acsmedchemlett.9b00106 Muscarinic acetylcholine receptor M2 2

Data from ChEMBL 36 via Core Engine