Compound Detail
CHEMBL4459999
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Cc1ccc2[nH]c(C)c(C(=O)Nc3ccc(Oc4ncnc5[nH]cc(-c6ccccc6)c45)c(F)c3)c(=O)c2c1
Basic Information
| ChEMBL ID | CHEMBL4459999 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | FLPHFGWAYHGHRS-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
519.5
MW (Da)
6.27
ALogP
5
HBA
3
HBD
112.8
PSA (Ų)
0.25
QED
2
Ro5 Violations
5
Rot. Bonds
Drug Information
| Molecule Type | Unknown |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 6.25
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Tyrosine-protein kinase receptor UFO CHEMBL4895 | IC50 | 6.25 | 6.25 | 560.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Tyrosine-protein kinase receptor UFO | IC50 | = | 560.0 | nM | 6.25 | Inhibition of human recombinant AXL incubated for 1 to 1.5 hrs by FRET based Z'-... | 27379978 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 27379978 | 10.1021/acs.jmedchem.6b00608 | Tyrosine-protein kinase receptor UFO | 1 |
Data from ChEMBL 36 via Core Engine