Assay Detail
Binding
CHEMBL4426892
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human recombinant AXL incubated for 1 to 1.5 hrs by FRET based Z'-Lyte kinase assay
44
Total Activities
44
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Tyrosine-protein kinase receptor UFO (CHEMBL4895) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
4-Oxo-1,4-dihydroquinoline-3-carboxamide Derivatives as New Axl Kinase Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 44 | 6.87 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4571241 | — | — | 1 | 8.40 |
| CHEMBL3809489 | BEMCENTINIB | 2.0 | 1 | 8.30 |
| CHEMBL460702 | BMS-777607 | 2.0 | 1 | 8.22 |
| CHEMBL4513513 | — | — | 1 | 8.22 |
| CHEMBL4449888 | — | — | 1 | 7.58 |
| CHEMBL4550377 | — | — | 1 | 7.52 |
| CHEMBL4449055 | — | — | 1 | 7.52 |
| CHEMBL4468711 | — | — | 1 | 7.47 |
| CHEMBL4473545 | — | — | 1 | 7.38 |
| CHEMBL4517938 | — | — | 1 | 7.21 |
| CHEMBL4456472 | — | — | 1 | 7.14 |
| CHEMBL4549099 | — | — | 1 | 7.13 |
| CHEMBL4588522 | — | — | 1 | 7.11 |
| CHEMBL4445218 | — | — | 1 | 7.11 |
| CHEMBL4593206 | — | — | 1 | 7.00 |
| CHEMBL4469879 | — | — | 1 | 7.00 |
| CHEMBL4541303 | — | — | 1 | 6.98 |
| CHEMBL4471186 | — | — | 1 | 6.82 |
| CHEMBL4516966 | — | — | 1 | 6.82 |
| CHEMBL4565473 | — | — | 1 | 6.82 |
| CHEMBL4583626 | — | — | 1 | 6.80 |
| CHEMBL4515742 | — | — | 1 | 6.77 |
| CHEMBL4464266 | — | — | 1 | 6.72 |
| CHEMBL4566072 | — | — | 1 | 6.70 |
| CHEMBL4470280 | — | — | 1 | 6.64 |
| CHEMBL4578200 | — | — | 1 | 6.32 |
| CHEMBL4458751 | — | — | 1 | 6.28 |
| CHEMBL4459999 | — | — | 1 | 6.25 |
| CHEMBL4437303 | — | — | 1 | 6.21 |
| CHEMBL4444198 | — | — | 1 | 6.05 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4571241 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL3809489 | BEMCENTINIB | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL4513513 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL460702 | BMS-777607 | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL4449888 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL4550377 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL4449055 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL4468711 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL4473545 | — | IC50 | = | 42.0 | nM | 7.38 |
| CHEMBL4517938 | — | IC50 | = | 61.0 | nM | 7.21 |
| CHEMBL4456472 | — | IC50 | = | 72.0 | nM | 7.14 |
| CHEMBL4549099 | — | IC50 | = | 74.0 | nM | 7.13 |
| CHEMBL4588522 | — | IC50 | = | 78.0 | nM | 7.11 |
| CHEMBL4445218 | — | IC50 | = | 78.0 | nM | 7.11 |
| CHEMBL4469879 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL4593206 | — | IC50 | = | 99.0 | nM | 7.00 |
| CHEMBL4541303 | — | IC50 | = | 105.0 | nM | 6.98 |
| CHEMBL4471186 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL4516966 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL4565473 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL4583626 | — | IC50 | = | 157.0 | nM | 6.80 |
| CHEMBL4515742 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL4464266 | — | IC50 | = | 192.0 | nM | 6.72 |
| CHEMBL4566072 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL4470280 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL4578200 | — | IC50 | = | 480.0 | nM | 6.32 |
| CHEMBL4458751 | — | IC50 | = | 530.0 | nM | 6.28 |
| CHEMBL4459999 | — | IC50 | = | 560.0 | nM | 6.25 |
| CHEMBL4437303 | — | IC50 | = | 620.0 | nM | 6.21 |
| CHEMBL4444198 | — | IC50 | = | 888.0 | nM | 6.05 |
| CHEMBL4445294 | — | IC50 | = | 1120.0 | nM | 5.95 |
| CHEMBL4558601 | — | IC50 | = | 1890.0 | nM | 5.72 |
| CHEMBL4458533 | — | IC50 | = | 3120.0 | nM | 5.51 |
| CHEMBL4548071 | — | IC50 | = | 3320.0 | nM | 5.48 |
| CHEMBL4470051 | — | IC50 | = | 4377.0 | nM | 5.36 |
| CHEMBL4452895 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4474599 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4453884 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4470872 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4454276 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4445176 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4558343 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4454283 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4472633 | — | IC50 | > | 10000.0 | nM | - |