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Compound Detail

CHEMBL4460095

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CC(C)CCC(=O)Nc1cccc(CCCNCC(O)c2ccc(O)c3[nH]c(=O)ccc23)c1

Basic Information

ChEMBL ID CHEMBL4460095
Phase Preclinical
Structure Type MOL
InChI Key PQYHRVMMOHBIOO-UHFFFAOYSA-N
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names

Molecular Properties

451.6
MW (Da)
3.86
ALogP
5
HBA
5
HBD
114.5
PSA (Ų)
0.28
QED
0
Ro5 Violations
11
Rot. Bonds

Drug Information

Molecule Type Unknown
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C26H33N3O4
MW 451.57
Aromatic Rings 3
Heavy Atoms 33
NP-Likeness -0.21

Activity Summary

EC50 2 meas. best 9.65

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Beta-2 adrenergic receptor
CHEMBL210
EC50 9.65 9.65 0.2 1
Beta-1 adrenergic receptor
CHEMBL213
EC50 5.71 5.71 1949.8 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
30392952 10.1016/j.bmc.2018.10.043 Beta-2 adrenergic receptor 2
30392952 10.1016/j.bmc.2018.10.043 Beta-1 adrenergic receptor 1
30392952 10.1016/j.bmc.2018.10.043 Unchecked 1

Data from ChEMBL 36 via Core Engine