Compound Detail
CHEMBL4461864
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Basic Information
| ChEMBL ID | CHEMBL4461864 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | QMZYZVGBMAHPDU-UHFFFAOYSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
336.4
MW (Da)
3.72
ALogP
3
HBA
0
HBD
32.8
PSA (Ų)
0.85
QED
0
Ro5 Violations
4
Rot. Bonds
Drug Information
| Molecule Type | Unknown |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 2 meas. best 7.26
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Sigma non-opioid intracellular receptor 1 CHEMBL287 | Ki | 7.26 | 7.26 | 55.0 | 1 |
| Mu-type opioid receptor CHEMBL233 | Ki | 6.4 | 6.4 | 401.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Sigma non-opioid intracellular receptor 1 | Ki | = | 55.0 | nM | 7.26 | Displacement of [3H]-(+)-pentazocine from human sigma-1 receptor expressed in HE... | 31743642 |
| Mu-type opioid receptor | Ki | = | 401.0 | nM | 6.4 | Displacement of [3H]-DAMGO from human MOR expressed in CHOK1 cell membranes incu... | 31743642 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 31743642 | 10.1021/acs.jmedchem.9b01256 | Mu-type opioid receptor | 3 |
| 31743642 | 10.1021/acs.jmedchem.9b01256 | Sigma non-opioid intracellular receptor 1 | 1 |
Data from ChEMBL 36 via Core Engine